Mycobacterium Tuberculosis INH Resistance

Apejuwe kukuru:

Ohun elo yii ni a lo lati ṣe awari ni iwọn-iyipada jiini ti 315th amino acid ti jiini katG (K315G>C) ati iyipada pupọ ti agbegbe olupolowo ti Jiini InhA (- 15 C>T).

Fi imeeli ranṣẹ si wa

Alaye ọja

ọja Tags

Orukọ ọja

HWTS-RT002A-Mycobacterium Tuberculosis Isoniazid Resistance Detection Kit (Pluorescence PCR)

Iwe-ẹri

Mianma FDA

Arun-arun

Isoniazid, oogun pataki kan ti o lodi si ikọ-igbẹ ti a ṣe ni 1952, jẹ ọkan ninu awọn oogun ti o munadoko julọ fun itọju apapọ ti iko-ara ti nṣiṣe lọwọ ati oogun kan fun iko-ara ti o wa latent.

KatG jẹ jiini akọkọ fifi koodu catalase-peroxidase ati iyipada jiini katG le ṣe igbelaruge iṣelọpọ ti ogiri sẹẹli mycolic acid, ṣiṣe awọn kokoro arun sooro si isoniazid.Ọrọ ikosile KatG jẹ ni ibamu pẹlu odi pẹlu awọn ayipada ninu INH-MIC, ati idinku 2-agbo ni awọn abajade ikosile katG ni ilosoke 2-agbo diẹ diẹ ninu MIC.Idi miiran ti isoniazid resistance ni mycobacterium tuberculosis waye nigba ti ifibọ ipilẹ, piparẹ tabi iyipada ba waye ninu ibi Jiini InhA ti iko mycobacterium.

ikanni

ROX	inhA (-15C>T) ojula ·
CY5	katG (315G>C) ojula
VIC (HEX)	IS6110

Imọ paramita

Ibi ipamọ	≤-18℃ Ninu okunkun
Selifu-aye	12 osu
Apeere Iru	Sputum
CV	≤5.0%
LoD	1 × 10³kokoro arun/ml
Ni pato	Aisi-agbelebu ifaseyin pẹlu awọn iyipada ti awọn aaye resistance oogun mẹrin (511, 516, 526 ati 531) ti jiini rpoB ni ita ibiti wiwa ti ohun elo wiwa. Awọn irinṣẹ to wulo: Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Yara Real-Time PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR eto LineGene 9600 Plus Real-Time PCR erin System MA-6000 Real-Time Quantitative Gbona Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System